Cross-diffusion systems for image processing: II. The nonlinear case

In this paper the use of nonlinear cross-diffu\-sion systems to model image restoration is investigated, theoretically and numerically. In the first case, well-posedness, scale-space properties and long time behaviour are analyzed. From a numerical point of view, a computational study of the performance of the models is carried out, suggesting their diversity and potentialities to treat image filtering problems. The present paper is a continuation of a previous work of the same authors, devoted to linear cross-diffusion models. \keywords{Cross-diffusion \and Complex diffusion \and Image restoration

A superconvergent linear FE approximation for the solution of an elliptic system of PDEs

The aim of this work is to study a nonstandard piecewise linear finite element method for elliptic systems of partial differential equations. This nonstandard method was considered by the authors for scalar elliptic equations and for a planar elasticity problem. The method enables us to compute a superconvergent numerical approximation to the solution of the system of partial differential equations.http://www.sciencedirect.com/science/article/B6TYH-4DTKSMT-1/1/3d2e49a86d0876f5ec457fcba0a29a2

O diário de viagem do tenente G.H. Preble (I)

Subtítulo: Contribuição para o estudo do início das relações diplomáticas • entre os Estados Unidos e o Japão

A Federação Brasileiro de Centros de Estudos Históricos e sua 1a Gestão

Reunidos em maio de 1967, na cidade de Belo Horizonte, Minas Gerais; os Centros de Estudos Históricos do país refundaram a Federação Brasileira de Centros de Estudos Históricos. Para congregar as atividades ligadas à História, no nível dos estudantes; faltava uma associação que coordenasse, e ao mesmo tempo propiciasse um maior intercâmbio entre as diferentes necessidades das diferentes regiões do Brasil. E êsse espaço foi preenchido pela Federação .

Immune cells and oxidative stress in the endotoxin tolerance mouse model

Sepsis is a systemic inflammatory response that can lead to tissue damage and death. In order to increase our understanding of sepsis, experimental models are needed that produce relevant immune and inflammatory responses during a septic event. We describe a lipopolysaccharide tolerance mouse model to characterize the cellular and molecular alterations of immune cells during sepsis. The model presents a typical lipopolysaccharide tolerance pattern in which tolerance is related to decreased production and secretion of cytokines after a subsequent exposure to a lethal dose of lipopolysaccharide. The initial lipopolysaccharide exposure also altered the expression patterns of cytokines and was followed by an 8- and a 1.5-fold increase in the T helper 1 and 2 cell subpopulations. Behavioral data indicate a decrease in spontaneous activity and an increase in body temperature following exposure to lipopolysaccharide. In contrast, tolerant animals maintained production of reactive oxygen species and nitric oxide when terminally challenged by cecal ligation and puncture (CLP). Survival study after CLP showed protection in tolerant compared to naive animals. Spleen mass increased in tolerant animals followed by increases of B lymphocytes and subpopulation Th1 cells. An increase in the number of stem cells was found in spleen and bone marrow. We also showed that administration of spleen or bone marrow cells from tolerant to naive animals transfers the acquired resistance status. In conclusion, lipopolysaccharide tolerance is a natural reprogramming of the immune system that increases the number of immune cells, particularly T helper 1 cells, and does not reduce oxidative stress.FAPESPCNP

Management of Colorectal Laterally Spreading Tumors: a Systematic Review and Meta-Analysis

Objective and study aims  To evaluate the efficacy and safety of different endoscopic resection techniques for laterally spreading colorectal tumors (LST). Methods  Relevant studies were identified in three electronic databases (PubMed, ISI and Cochrane Central Register). We considered all clinical studies in which colorectal LST were treated with endoscopic resection (endoscopic mucosal resection [EMR] and/or endoscopic submucosal dissection [ESD]) and/or transanal minimally invasive surgery (TEMS). Rates of en-bloc/piecemeal resection, complete endoscopic resection, R0 resection, curative resection, adverse events (AEs) or recurrence, were extracted. Study quality was assessed with the Newcastle-Ottawa Scale and a meta-analysis was performed using a random-effects model. Results  Forty-nine studies were included. Complete resection was similar between techniques (EMR 99.5 % [95 % CI 98.6 %-100 %] vs. ESD 97.9 % [95 % CI 96.1 - 99.2 %]), being curative in 1685/1895 (13 studies, pooled curative resection 90 %, 95 % CI 86.6 - 92.9 %, I 2  = 79 %) with non-significantly higher curative resection rates with ESD (93.6 %, 95 % CI 91.3 - 95.5 %, vs. 84 % 95 % CI 78.1 - 89.3 % with EMR). ESD was also associated with a significantly higher perforation risk (pooled incidence 5.9 %, 95 % CI 4.3 - 7.9 %, vs. EMR 1.2 %, 95 % CI 0.5 - 2.3 %) while bleeding was significantly more frequent with EMR (9.6 %, 95 % CI 6.5 - 13.2 %; vs. ESD 2.8 %, 95 % CI 1.9 - 4.0 %). Procedure-related mortality was 0.1 %. Recurrence occurred in 5.5 %, more often with EMR (12.6 %, 95 % CI 9.1 - 16.6 % vs. ESD 1.1 %, 95 % CI 0.3 - 2.5 %), with most amenable to successful endoscopic treatment (87.7 %, 95 % CI 81.1 - 93.1 %). Surgery was limited to 2.7 % of the lesions, 0.5 % due to AEs. No data of TEMS were available for LST. Conclusions  EMR and ESD are both effective and safe and are associated with a very low risk of procedure related mortality.info:eu-repo/semantics/publishedVersio

Guinea grass and its effects on the initial growth of Eucalyptus 7 urograndis clones

Esta pesquisa teve o objetivo de avaliar o efeito da conviv\ueancia de capim-coloni\ue3o sobre o crescimento inicial de plantas de clones de eucalipto. Foram instalados dois ensaios com mudas de clones de eucalipto e de capim-coloni\ue3o, que cresceram em parcelas delimitadas lateralmente por paredes de alvenaria preenchidas com terra. O primeiro ensaio obedeceu ao delineamento experimental inteiramente casualizado, com tr\ueas repeti\ue7\uf5es, e tratamentos em esquema fatorial 5 x 2 (cinco clones de eucalipto, e a aus\ueancia ou presen\ue7a de duas plantas de capim-coloni\ue3o plantadas a 10 cm da muda de eucalipto). O segundo ensaio foi semelhante ao primeiro, por\ue9m, com apenas tr\ueas clones de eucalipto, cinco repeti\ue7\uf5es, e tratamentos em esquema fatorial 3 x 2 (tr\ueas clones de eucalipto e a aus\ueancia ou presen\ue7a de capim-coloni\ue3o). Os clones de eucalipto n\ue3o afetaram de modo diferenciado o crescimento de capim-coloni\ue3o, sendo que aqueles que conviveram com a planta daninha n\ue3o apresentaram diferen\ue7a no seu desenvolvimento, igualando-os quando sob competi\ue7\ue3o. As caracter\uedsticas dos clones de eucalipto mais sens\uedveis \ue0 conviv\ueancia com capim-coloni\ue3o foram: \ue1rea foliar, mat\ue9ria seca de folhas e caule. O clone 3 foi o que se mostrou mais sens\uedvel \ue0 conviv\ueancia com capim-coloni\ue3o e o clone 1 mais tolerante, por\ue9m todos os clones estudados tiveram influ\ueancia negativa da conviv\ueancia com capim-coloni\ue3o.This study aimed to evaluate the guinea grass effect ( Panicum maximum ) on the initial growth of different Eucalyptus 7 urograndis clones. Two assays were established with eucalyptus clones and guinea grass seedlings. The plants were grown in plots with cement borders filled with soil. Each plot received a eucalyptus seedling. The first assay had a completely randomized experimental design, with three replications, and treatments in a 5x2 factorial scheme (five eucalyptus clones and the absence or presence of two guinea grass plants at 10 cm distance from eucalyptus seedling). The second assay was similar to the first, however with three eucalyptus clones. The experimental design was completely randomized, with five replications, and a 3x2 factorial scheme (three eucalyptus clones and the absence or presence of two guinea grass plants). The presence of eucalyptus clones did not affect guinea grass development. The eucalyptus clones that coexisted with guinea grass plants did not show differences in their development, making the clones equal when under competition. The most susceptible characteristics of eucalyptus clones to guinea grass were foliar area, shoot and stem dry matter. Clone 3 showed the most sensitivity to guinea grass, and clone 1 was the most tolerant, but all clones studied suffered a negative interference from guinea grass

Mature autologous dendritic cell vaccines in advanced non-small cell lung cancer: a phase I pilot study

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Background: Overall therapeutic outcomes of advanced non-small-cell lung cancer (NSCLC) are poor. The dendritic cell (DC) immunotherapy has been developed as a new strategy for the treatment of lung cancer. The purpose of this study was to evaluate the feasibility, safety and immunologic responses in use in mature, antigen-pulsed autologous DC vaccine in NSCLC patients. Methods: Five HLA-A2 patients with inoperable stage III or IV NSCLC were selected to receive two doses of 5 x 107 DC cells administered subcutaneous and intravenously two times at two week intervals. The immunologic response, safety and tolerability to the vaccine were evaluated by the lymphoproliferation assay and clinical and laboratorial evolution, respectively. Results: The dose of the vaccine has shown to be safe and well tolerated. The lymphoproliferation assay showed an improvement in the specific immune response after the immunization, with a significant response after the second dose (p = 0.005). This response was not long lasting and a tendency to reduction two weeks after the second dose of the vaccine was observed. Two patients had a survival almost twice greater than the expected average and were the only ones that expressed HER-2 and CEA together. Conclusion: Despite the small sample size, the results on the immune response, safety and tolerability, combined with the results of other studies, are encouraging to the conduction of a large clinical trial with multiples doses in patients with early lung cancer who underwent surgical treatment.30Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Department of Radiology of the Hospital Estadual Sumare UNICAMPSCOGConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)CNPq [401327/05-1

Vitamin D nutritional status and vitamin D regulated antimicrobial peptides in serum and pleural fluid of patients with infectious and noninfectious pleural effusions

Background: Vitamin D and vitamin D dependent antimicrobial peptides such as Cathelicidin (LL-37) and ?-defensin 2 have an important role in innate and adaptative immunity, but their role in pleural effusions has not been studied before. Methods: Serum and pleural fluid samples from 152 patients with pleural effusion were collected, corresponding to 45 transudates and 107 exudates, 51 infectious effusions (14 complicated and 37 non-complicated), 44 congestive heart failure effusions and 38 malignant effusions. The levels of 25 OH-vitamin D, 1,25-(OH)2-vitamin D, Vitamin D Binding Protein (VDBP), LL-37 and ?-defensin 2, both in serum and pleural fluid were evaluated in this prospective study. Differences between groups were analysed using unpaired t tests or Mann?Whitney tests. Correlations between data sets were examined using Pearson correlation coefficient or Spearman rank correlation coefficient. Diagnostic accuracy was estimated using ROC curve analysis. Results: Low serum 25 OH vitamin D levels were found in all groups. Infectious effusions (IE) had higher serum and pleural fluid LL-37 levels compared to congestive heart failure or malignant effusions. Among IE, complicated had higher serum and pleural fluid LL-37 levels, and lower serum ?-defensin-2 levels. Positive correlations were found between serum 25 OH-vitamin D levels and serum or pleural 1,25-(OH)2-vitamin D levels, and between 1,25-(OH) 2-vitamin D and LL-37 serum. Diagnostic accuracy of the different molecules was moderate at best. Conclusions: Hypovitaminosis D is highly prevalent in pleural effusions. LL-37 is produced intrapleurally in IE. This production is higher in complicated IE. No evidence of pleural production of ?-defensin 2 was found in any of the groups. Diagnostic accuracy of the different molecules is at the best moderate for discriminating different types of effusions